UH3 Project: Guiding Good Choices for Health (GGC4H): Testing Feasibility and Effectiveness of Universal Parent-Focused Prevention in Three Healthcare Systems
Overview
Principal Investigators:
Sponsoring Institution: University of Washington
Collaborators:
- Kaiser Permanente
- Henry Ford Health System
NIH Institute Providing Oversight: National Center for Complementary and Integrative Health (NCCIH)
Program Official: Beda Jean François, PhD (NCCIH)
Project Scientists: Elizabeth Ginexi, PhD (NCCIH)
ClinicalTrials.gov Identifier: NCT04040153
Trial Status: Enrolling
Trial Summary
Fifty percent of all adolescents will use some form of illicit drugs before the end of high school, 20-25% will meet criteria for depression, and many others will engage in health compromising behaviors like delinquency and violence—with consequences for their long-term health. Evidence-based parenting interventions shown to prevent these behavioral health concerns could improve adolescent health trajectories if implemented widely in pediatric primary care. The American Academy of Pediatrics’ Bright Futures recommends that pediatricians offer developmentally tailored anticipatory guidance to all parents to support their children’s healthy development, but programs providing guidance are not offered universally. This UG3-UH3 application tests the feasibility and effectiveness of implementing Guiding Good Choices, a universal, evidence-based anticipatory guidance curriculum for parents of early adolescents, in three large, integrated healthcare systems serving socioeconomically diverse families. This intervention reduced adolescent alcohol, tobacco and marijuana use, depression, and delinquent behavior in two previous randomized controlled trials. It also strengthened parenting practices and parent-adolescent relationship quality, both broadly protective against behavioral health concerns. Guiding Good Choices has the capacity to achieve population-level impact on adolescent health if made widely available through pediatric primary care. Parents trust pediatricians’ advice regarding their children’s well-being, and current research with socioeconomically diverse groups suggests that they are eager to participate in family-focused programs offered in primary care clinics. Building on this body of research, the investigative team, in close cooperation with the NIH Healthcare Systems Research Collaboratory and healthcare systems partners, will conduct a cluster-randomized trial of Guiding Good Choices in 72 pediatric primary care practices, across three heterogeneous health care systems (HCS). Half will be randomly assigned to recommend the program universally to parents of 12-year-old adolescents, and half will serve as usual care controls. Using a workflow that is easy to adopt, implement and maintain, at each adolescent’s 12-year-old well visit, primary care pediatricians will recommend that parents enroll in the intervention. We anticipate recruiting over 3,600 families into the trial prior to beginning the intervention. The team will use the RE-AIM framework to test implementation outcomes and effectiveness, including hypothesized reductions in the study’s primary outcome of substance use initiation and several secondary behavioral health problems (e.g., substance use frequency, mood symptoms and diagnoses, delinquency) and some exploratory outcomes (e.g., emergency department and inpatient service utilization). We will use data from an Adolescent Behavioral Health Survey and the EHR to monitor outcomes up to 3 years post intervention. We will also assess the feasibility and sustainability of implementing the intervention in each HCS, including health economic evaluation to understand costs in relation to value gained. Throughout the trial the investigative team will engage in ongoing dialog with HCS leaders, pediatricians, and clinic staff to ensure the intervention and implementation process fit the needs of each HCS. We anticipate that evidence of feasibility and effectiveness in three different HCS will foster broad dissemination to achieve public health impact.
Data and Resource Sharing
- GGC4H-2019-UH3 Follow-up
GGC4H-Ethics and Regulatory UH3 Follow-up
- GGC4H Ethics and Regulatory Discussion
GGC4H Ethics and Regulatory Discussion
Featured Interviews
Drs. Catalano, Kuklinkski, and Sterling discuss testing feasibility and effectiveness of Guiding Good Choices program across three health systems.
News and Interviews
- News_Pragmatic Trials Researchers Share Lessons From Collecting Patient-Reported Outcomes in the Electronic Health Record
January 8, 2024: Pragmatic Trials Researchers Share Lessons From Collecting Patient-Reported Outcomes in the Electronic Health Record
- News_Wealth of New Insights From the NIH Pragmatic Trials Collaboratory
December 13, 2022: In Our Tenth Year, a Wealth of New Insights From the NIH Pragmatic Trials Collaboratory
- Video_Update on the GGC4H Demonstration Project
Video Interview: Update on the GGC4H NIH Collaboratory Trial
- News_Biostatistics Core Develops Tools and Strategies for Common Research Challenges
August 16, 2022: Biostatistics Core Develops Tools and Strategies for Common Research Challenges
- News_GGC4H Guides Parents and Teens Toward Better Health Amid Challenging Times
May 31, 2022: GGC4H Guides Parents and Teens Toward Better Health Amid Challenging Times
- News_Guiding Good Choices for Health (GGC4H) Pragmatic Trial Enrolls First Participant
October 11, 2019: Guiding Good Choices for Health (GGC4H) Pragmatic Trial Enrolls First Participant
- News_GGC4H Awarded Continuation From Planning to Implementation Phase
June 25, 2019: GGC4H Awarded Continuation From Planning to Implementation Phase
- News_Spotlight on a New Demonstration Project_GGC4H
September 5, 2018: Spotlight on a New NIH Collaboratory Trial: GGC4H
- Video interview with Dr. Richard Catalano
Video Interview: Interview with Dr. Richard Catalano, Co-Principal Investigator of GGC4H
Publications
- Scheuer et al Contemp Clin Trials 2022
GGC4H Study Design Paper
- Richesson et al J Am Med Inform Assoc 2021
Enhancing the use of EHR systems for pragmatic embedded research: lessons from the NIH Health Care Systems Research Collaboratory
- Living Textbook Chapter_Which PCTs Should Have a DMC
Living Textbook Chapter: Which PCTs Should Have a DMC?
- Living Textbook_The Embedded Pragmatic Trials Ecosystem
Living Textbook: The Embedded Pragmatic Clinical Trial Ecosystem
- GGC4H Study Snapshot
GGC4H Study Snapshot
Presentations
- SRCD-GBD-Sterling_3-25-23_final
Extending the Reach of Guiding Good Choices through Primary Care-based Implementation with LatinX Families
- GR-Video-03-03-23
Adoption, Implementation and Sustainment of Family-focused Prevention in Health Care Systems: How Do We Get There? (GR Video 2023)
- GR-Slides-03-03-23
Adoption, Implementation and Sustainment of Family-focused Prevention in Health Care Systems: How Do We Get There? (GR Slides 2023)
- GGC4H (AcademyHealth 2023)_FINAL
Case Study - GGC4H - AcademyHealth 2023
- 2023 AcademyHealth Workshop_Day 2_Mor_ePCTs in Context
ePCTs in Context-Day 2-AcademyHealth 2023
- 2023 AcademyHealth Workshop_Day 1_Weinfurt_ePCTs in Context
ePCTs in Context-Day 1
- SPR_2023 GGC4H Symposium_Intro_6.1.2023
Guiding Good Choices for Health: Increasing the Reach of Effective Family-Focused Intervention Through Virtual Implementation in Pediatric Primary Care
- Morrison_SPR 2023
Assessing Implementation Fidelity of the Guiding Good Choices Program in a Virtual Environment
- GGC ICEPS_June 2023
The Guiding Good Choices Program: Exploring Innovations to Support Parents and Promote Youth Wellbeing Presentation
- Scheuer_SPR 2023 01Jun2023
Virtual Implementation of Guiding Good Choices: Lessons Learned from Intervention Adaptation in Response to COVID-19
- Sterling_SPR 2023 01Jun2023
Barriers and Facilitators to Implementation and Sustainability of Guiding Good Choices in Integrated Healthcare Systems
- SC-Mtg-2023-Day1-Sterling
Stacy Sterling Presentation at 2023 Steering Committee Meeting
- 2022 NIH Workshop_Panel 4
2022 NIH Workshop Panel 4
- SC-Mtg-2022-Day-2-Kuklinski
GGC4H Presentation at 2022 Steering Committee Meeting
- GR-Video-06-25-21
Inclusion of Diverse Participants in Pragmatic Clinical Trials: Meeting Participants Where They Are – Outreach, Trust, and Consent to Maximize Diversity
- GR-Slides-06-25-21
Inclusion of Diverse Participants in Pragmatic Clinical Trials: Meeting Participants Where They Are – Outreach, Trust, and Consent to Maximize Diversity
- SC-2019-UG3-GGC4H
UG3 Updates at the 2019 SC Meeting-GGC4H
- Presentation_GGG4H_SocPrevRes_2019_c
Guiding Good Choices: Adaptations for Context (SPR 2019)
- GR-Video-12-14-18
Guiding Good Choices for Health (GGC4H): Testing Feasibility and Effectiveness of Universal Parent-Focused Prevention in Three Healthcare Systems (GR Video 2018)
- GR-Slides-12-14-18
Guiding Good Choices for Health (GGC4H): Testing Feasibility and Effectiveness of Universal Parent-Focused Prevention in Three Healthcare Systems (GR Slides 2018)
- 1.-Catalano-Kuklinski-Sterling_P4TH-15-min-FINAL_revised
A New Pragmatic Trial: Parents, Pediatricians, and Prevention: Pathways to Adolescent Health
- Presentation_GGC4H_CTN_2018_c
Parents, Pediatricians, and Prevention: Pathways to Adolescent Health (NIDA CTN 2018)