COVID-19 Resources

The NIH Collaboratory Coordinating Center is committed to staying connected with our stakeholder organizations, Core Working Group members, NIH Collaboratory Trial teams, and the broader research community by sharing late-breaking research and promoting resources in support of clinical researchers affected by the COVID-19 public health emergency.

We are hosting Grand Rounds educational sessions on COVID-19−related topics, as well as sharing timely news and resources. Please see below for the latest information.

News and Announcements | Upcoming Grand Rounds | Publications | Grand Rounds Recordings

Research Tools and Guidance

COVID-19 Checklist for Statistical Analysis Plans in Pragmatic Trials: This tool from the NIH Collaboratory assists investigators in identifying impacts of the COVID-19 public health emergency on ongoing pragmatic clinical trials by summarizing impacts on trial conduct that study teams should document, measure, analyze, and report.
NIH Public Health Emergency and Disaster Research Response (DR2) Repository of COVID-19 Research Tools: COVID-19–related data collection tools that are currently in use, with verified sources and contact information.
PMC Coronavirus Pandemic Measures: Outcome assessment tool from the Pain Management Collaboratory to ascertain factors that may influence pain-related pragmatic clinical trials due to the COVID-19 pandemic.

More Resources

Coronavirus.gov: The latest public health information from the Centers for Disease Control and Prevention.
NIH Coronavirus (COVID-19) Resources: The latest research information from the National Institutes of Health.
National COVID Cohort Collaborative (N3C): Resources from the National Center for Data to Health.
LitCovid: A curated literature hub for COVID-19 from the National Library of Medicine.

COVID-19 News and Announcements

Upcoming Grand Rounds

January 6, 2023: Outpatient Treatment of COVID-19 With Metformin, Ivermectin, or Fluvoxamine: 10-Month Follow-up and Effects on Developing Long COVID (Carolyn Bramante, MD, MPH; Thomas Murray, PhD)

COVID-19 Grand Rounds Recordings

October 28, 2022: "The HERO (Healthcare Worker Exposure Response & Outcomes) Program: An Online Community to Support Observational Studies, Randomized Trials, and Long-Term Safety Surveillance" (Emily O’Brien, PhD, FAHA; Russell Rothman, MD, MPP)
July 29, 2022: "Effect of Early Treatment With Single-dose Pegylated Interferon Lambda Among Patients With COVID 19: Results From The TOGETHER Trial" (Edward Mills, PhD; Jeffrey S. Glenn, MD, PhD)
July 22, 2022: "ACTIV-6 Reaches 1 Year, Will Share Results in COVID-19 Grand Rounds" (Susanna Naggie, MD, MHS)
July 15, 2022: "Overview of Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) Public-Private Partnership and Lessons Learned" (Stacey J. Adam, PhD)
July 8, 2022: "Results From the COVID-OUT Trial, a Phase-3 Trial of Outpatient Treatment for COVID-19 Using Metformin, Ivermectin, and Fluvoxamine" (Carolyn Bramante, MD, MPH; Thomas Murray, PhD; Jared Huling, PhD)
May 20, 2022: "Long-COVID Studies Within the RECOVER Platform" (Upinder Singh, MD)
April 8, 2022: "COVID-19 Surveillance in PCORnet: Year 2 Update" (Jason Block, MD, MPH; Thomas W. Carton, PhD, MS)
March 18, 2022: "Better Data on Ivermectin Is Finally Here: Results From the TOGETHER Trial" (Edward Mills, PhD; Craig Rayner, PharmD)
March 4, 2022: "ACP COVID: A Trial to Evaluate an Advance Care Planning Video and Communication Skills Training Intervention for Older Adults During an Evolving Pandemic" (Angelo E. Volandes, MD, MPH; James A. Tulsky, MD; Sophia N. Zupanc, BA)
January 14, 2022: "Searching for a Unicorn: Understanding Stakeholder Perspectives When Selecting Outcomes for Outpatient Trials" (Christopher John Lindsell, PhD)
November 12, 2021: "Using Financial Incentives to Increase COVID-19 Vaccine Uptake" (Charlene Wong, MD, MSPH)
October 15, 2021: "The Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in Bangladesh" (Jason Abaluck, PhD)
October 1, 2021: "COVID-OUT: From Computer Modeling to a Phase III Trial of Early Outpatient Treatment for SARS-CoV-2 Infection" (Carolyn Bramante, MD, MPH; Thomas Murray, PhD; Jared Huling, PhD)
August 20, 2021: "Fluvoxamine for Early Treatment of COVID-19: The STOP COVID Clinical Trials" (Eric Lenze, MD)
August 13, 2021: "Got Anything for This Cough? Outpatient Treatment Trials in the Time of COVID" (Davey Smith, MD)
August 6, 2021: "The TOGETHER Early Treatment of COVID Trial: Building Platform Trial Infrastructure for Infectious Diseases" (Edward Mills, PhD)
July 23, 2021: "Long Term COVID Patient Engagement: Best Practices Informed By Patients’ Experiences Seeking Medical Care" (Diana Berrent, JD; Natalie Lambert, PhD; Nick Guthe)
July 9, 2021: "COVID-19 Vaccine Efficacy Studies: Challenges and Successes" (Hana El Sahly, MD)
May 21, 2021: "The PRINCIPLE Adaptive Platform Trial for Community Treatment of COVID-19: Innovation in Trial Design and Delivery" (Chris Butler, MD; Ben Saville, PhD)
May 7, 2021: "Online Recruitment in the Era of COVID-19: Pitfalls and Progress" (Megan L. Ranney, MD, MPH)
April 30, 2021: "ACTIV-6: A Direct-to-Participant Platform Trial of Repurposed Drugs for COVID-19 in Non-hospitalized Patients" (Susanna Naggie, MD, MHS; Elizabeth Shenkman, PhD)
April 23, 2021: "COVID Clinical Trials: the Intermountain Healthcare Experience" (Samuel M. Brown, MD, MS)
April 16, 2021: Minnesota EHR Consortium COVID-19 Project: A Statewide Collaboration to Inform Vaccine Equity (Paul E. Drawz, MD, MHS, MS; Tyler Winkelman, MD, MSc)
April 9, 2021: "Taking Research to the Participant: Experiences With TREAT NOW, a No-Touch COVID-19 Trial" (Adit Ginde, MD, MPH)
April 2, 2021: "Lessons From COVID-19: The First Year of the REMAP-CAP Global Adaptive Platform Trial" (Derek C. Angus, MD, MPH)
March 19, 2021: "HERO–Learning Together About Vaccines for SARS-CoV-2" (Emily C. O'Brien, PhD; Robert M. Califf, MD)
March 12, 2021: "Lessons Learned From the Gates MRI Virtual COVID-19 Trial" (Mohamed Bassyouni, PharmD; Jintanat Ananworanich, MD, PhD)
March 5, 2021: "Data and Safety Monitoring Boards for Trials of COVID-19 Treatments and Vaccines: The Challenges" (Susan S. Ellenberg, PhD)
February 19, 2021: "Beyond Politics: Beyond Politics: Promoting COVID Vaccination in the US" (Kevin A. Schulman, MD)
February 5, 2021: Generating High-Quality Evidence During a Pandemic: The Brazilian COALITION Experience (Renato Lopes, MD, MHS, PhD)
January 29, 2021: "The COVID-19 Citizen Science Study" (Gregory M. Marcus, MD, MAS)
January 15, 2021: "How CTTI and the Clinical Trials Community Have Risen to Meet the Challenge of the COVID-19 Pandemic" (Pamela Tenaerts, MD, MBA)
January 8, 2021: "HERO-Together: Building Vaccine Confidence With Long-Term Outcomes Data" (Emily C. O'Brien, PhD)
December 11, 2020: "PREVENTABLE: Starting a Pragmatic Trial in a Pandemic" (Karen P. Alexander, MD; W. Schuyler Jones, MD)
October 30, 2020: "Lessons From Virtual Trials in the Time of a Pandemic: Minnesota Hydroxychloroquine Experience" (David R. Boulware, MD, MPH, CTropMed)
October 16, 2020: "Back to School, It’s More Than Just a Trip to Target This Year: The ABC Science Collaborative" (Danny Benjamin, MD, PhD; Kanecia Zimmerman, MD, MPH)
September 25, 2020: "Accelerating the Nation's COVID-19 Testing Capacity: An Update From the NIH's RADx Program" (Rick Bright, PhD; Rachael Fleurence, PhD)
September 11, 2020: "Launching CONNECTS: Collaborating Network of Networks for Evaluating COVID-19 and Therapeutic Strategies" (Gordon R. Bernard, MD; Sonia Thomas, DrPH)
August 21, 2020: "Adaptive Platform Trials: Scalable From Breast Cancer to COVID" (Laura Esserman, MD, MBA)
July 10, 2020: "COVID Open Science Collaborative Analytics Platform: National COVID Cohort Collaborative (N3C)" (Ken Gersing, MD; Robert A. Star, MD)
June 5, 2020: "PCORnet COVID-19 Common Data Model Design and Results" (Thomas Carton, PhD, MS; Keith Marsolo, PhD; Jason Perry Block, MD, MPH)
May 15, 2020: "Optimizing Learning While Doing: The REMAP-CAP Adaptive Platform Trial" (Derek C. Angus, MD, MPH, FRCP)
May 1, 2020: “Can the COVID-19 Crisis Lead to Reformation of the Evidence Generation Ecosystem?" Keynote address for EHR Workshop Grand Rounds Series: “Advances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials” (Robert M. Califf, MD, MACC)
April 24, 2020: “The RECOVERY Trial: A UK National Platform Trial of Potential Treatments for Patients Hospitalised With COVID-19” (Martin Landray, PhD, FRCP)
April 17, 2020: “The HERO Program: PCORnet® at Work to Create a Healthcare Worker Community for Rapid Cycle Evidence” (Nakela Cook, MD, MPH; Josie Briggs, MD; Susanna Naggie, MD; Emily O’Brien, PhD; Russell Rothman, MD; Chris Forrest, MD, PhD)
April 10, 2020: “Hydroxychloroquine for the Early Treatment of COVID-19 in Hospitalized Adults: A Multicenter Randomized Clinical Trial” (Sean Collins, MD, MSc)
April 3, 2020: “Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): Participant-Centered, Rapidly-Deployed, Digitally-Enabled Research” (Harlan Krumholz, MD; Bala Hota, MD, MPH; Graham Nichol, MD, MPH)
March 20, 2020: "Clinical Trials in the Time of COVID-19" (Susanna Naggie, MD; Adrian Hernandez, MD, MHS; Eric Perakslis, PhD)

COVID-19 Publications

Experiences and insights from the early US COVID-19 epicenter: a Rapid Assessment Procedure Informed Clinical Ethnography case series. Psychiatry. 2020;83(2):115-127. doi: 10.1080/00332747.2020.1750214.
Trends in emergency department visits and hospital admissions in health care systems in 5 states in the first months of the COVID-19 pandemic in the US. JAMA Intern Med. 2020;180(10):1328-1333. doi: 10.1001/jamainternmed.2020.3288.
Rapid ethnographic assessment of the COVID-19 pandemic April 2020 'surge' and its impact on service delivery in an acute care medical emergency department and trauma center. BMJ Open. 2020;10(10):e041772. doi: 10.1136/bmjopen-2020-041772.
Clinical outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19) in Boston. J Gen Intern Med. 2021;36(5):1285-1291. doi: 10.1007/s11606-021-06622-x.
Emergency department visits for nonfatal opioid overdose during the COVID-19 pandemic across 6 US healthcare systems. Ann Emerg Med. 2021 Mar 18. doi: 10.1016/j.annemergmed.2021.03.013. Epub ahead of print.
Association of an advance care planning video and communication intervention with documentation of advance care planning among older adults: a nonrandomized controlled trial. JAMA Netw Open. 2022 Feb 1;5(2):e220354. doi: 10.1001/jamanetworkopen.2022.0354.
Rapid ethnographic assessment of the impact of the COVID-19 pandemic on mental health services delivery in an acute care medical emergency department and trauma center. Adm Policy Ment Health. 2022 Mar;49(2):157-167. doi: 10.1007/s10488-021-01154-2.
Patient factors and hospital outcomes associated with atypical presentation in hospitalized older adults with COVID-19 during the first surge of the pandemic. J Gerontol A Biol Sci Med Sci. 2022;77(4):e124-e132. doi: 10.1093/gerona/glab171.
Leveraging emergency department information systems to address palliative care needs of ED patients during the COVID pandemic Am J Hosp Palliat Care. 2022;39(5):581-583. doi: 10.1177/10499091211042854.
The impact of COVID-19 on pragmatic clinical trials: lessons learned from the NIH Health Care Systems Research Collaboratory. Trials. 2022;23(1):424. doi: 10.1186/s13063-022-06385-8.