Coordinating Center
Overview
Coordinating Center Leadership
Duke Clinical Research Institute
Harvard Pilgrim Health Care Institute
Kaiser Permanente Washington Health Research Institute
Meet our Coordinating Center staff
Core Working Groups
The Coordinating Center provides technical support and pragmatic trial expertise for Collaboratory trials and initiatives via 7 Core Working Groups, each focused on a specific topic. Core membership also includes representatives from NIH and the Collaboratory NIH Collaboratory Trials, who contribute to the cross-cutting knowledge generated by the program.
To meet the Core Working Group Leadership, please visit the Core pages.
- Biostatistics and Study Design
- Ethics and Regulatory
- Electronic Health Records
- Health Care Systems Interactions
- Health Equity
- Implementation Science
- Patient-Centered Outcomes
The Core Working Groups have produced extensive resources for the research community. Learn more on each Core Working Group webpage.
The NIH Pragmatic Trials Collaboratory Coordinating Center serves the following functions:
- Provide national leadership and technical expertise in all aspects of research with healthcare systems
- Work with the NIH to produce, document, and disseminate standards for healthcare systems research
- Create durable infrastructure that facilitates multicenter studies and the responsible use of electronic health data
- Support synergy among the Core Working Groups, NIH Collaboratory Trials, and Collaboratory committees
- Coordinate communication and dissemination within the Collaboratory and to the broader research community
Partnering Organizations
The NIH Pragmatic Trials Collaboratory builds upon and contributes to the work of several organizations engaged in related efforts. It has a close partnership with the National Patient-Centered Clinical Research Network (PCORnet).
Other stakeholder organizations include the following:
- Agency for Healthcare Research and Quality
- Clinical & Translational Science Awards
- Clinical Trials Transformation Initiative
- Helping to End Addition Long-term
- National Academy of Medicine
- NIA IMPACT Collaboratory: Transforming Dementia Care
- National Institute of Health
- Office of the National Coordinator for Health Information Technology
- Patient-centered Outcomes Research Institute
- All of Us Research Program
- U.S. Food and Drug Administration (including its Sentinel Initiative)
Publications
- Marsolo et al Ann Intern Med 2023
Moving from idealism to realism with data sharing
- Staman et al Contemp Clin Trials 2023
Intervention delivery for embedded pragmatic clinical trials: Development of a tool to measure complexity
- O'Brien et al Trials 2022
The impact of COVID-19 on pragmatic clinical trials: lessons learned from the NIH Health Care Systems Research Collaboratory
- Platt et al N Engl J Med 2021
Is learning worth the trouble? Improving health care system participation in embedded research
- Simon et al Healthc (Amst) 2020
Disseminating trial results: we can have both faster and better
- Simon et al N Engl J Med 2020
Evidence from pragmatic trials — slouching toward a learning health system
- Curtis et al Clin Trials 2019
Addressing guideline and policy changes during pragmatic clinical trials
- Simon et al Ann Intern Med 2017
Data sharing and embedded research
- Califf et al JAMA 2012
The future of cardiovascular clinical research: informatics, clinical investigators, and community engagement
- Weinfurt et al BMC 2017
Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory
- Califf and Platt JAMA 2013
Embedding cardiovascular research into practice