May 16, 2022: New Training Workshop on the Essentials of Embedded Pragmatic Clinical Trials Now Available

The NIH Pragmatic Trials Collaboratory is pleased to announce a new training workshop now available on the ePCT Training Workshop webpage.

On April 11, 2022, the NIH Pragmatic Trials Collaboratory hosted a Pre-Conference Workshop, Essentials of Embedded Pragmatic Clinical Trials, at the 2022 Health Care Systems Research Network (HCSRN) Annual Conference.

This training workshop introduces concepts in the design, conduct, and implementation of embedded pragmatic clinical trials (ePCTs), and provides firsthand ePCT experiences and case studies from the NIH Pragmatic Trials Collaboratory Trials.

View the workshop slides and additional resources on the NIH Pragmatic Trials Collaboratory website.

Visit the ePCT Training Resources webpage for more resources, including self-study guides, handouts, and video modules.

May 20, 2021: Materials from the Recent HCSRN ePCT Workshop Are Available

Logo for HCSRN 2021

The Health Care Systems Research Network (HCSRN), in partnership with the NIH Health Care Systems Research Collaboratory, presented a virtual workshop on Essentials of Embedded Pragmatic Clinical Trials (ePCTs) on May 11-12, 2021. The sessions introduced concepts in the design, conduct, and implementation of ePCTs, with a particular focus on methods relevant to health services researchers.

View the HCSRN Workshop slides and recordings.

Visit the ePCT Training Resources webpage for more resources, including self-study guides, handouts, and video modules.

January 5, 2021: New Video Collection Highlights Advances in Electronic Health Records for Pragmatic Research

We are pleased to announce our new collection of short educational videos that highlight advances in the use of electronic health records (EHRs) in pragmatic clinical trials.

The videos are drawn from our 2020 EHR Workshop Grand Rounds Series, “Advances at the Intersection of Digital Health, Electronic Health Records and Pragmatic Clinical Trials.” The series highlighted advances in digital health, new approaches and evolving standards for EHRs, and implications for researchers conducting pragmatic trials. Experts discuss the evolving regulatory context for EHRs, national policy priorities, and innovative uses of EHRs in several NIH Collaboratory Trials.

Video topics include:

Visit the EHR Workshop Video Modules page for access to all of the new videos.

April 1, 2019: Pre-Conference Seminar on Essentials of ePCTs Offered at AcademyHealth’s June 2019 Annual Research Meeting in D.C.

The NIH Collaboratory is partnering with AcademyHealth to offer a full-day pre-conference seminar at the 2019 Annual Research Meeting in Washington, D.C. Essentials of Embedded Pragmatic Clinical Trials will provide an introduction to the investigative opportunities for embedded health systems research, along with strategies for conducting clinical trials that provide real-world evidence necessary to inform both practice and policy. Firsthand ePCT experiences and case studies from the NIH Collaboratory will support and illustrate the topics presented. Speakers will include program officers and senior staff from NIH Institutes and Centers and senior investigators from the NIH Collaboratory Trials and Coordinating Center.

Learning objectives include:

  • To clarify the definition of ePCTs and explain their utility.
  • To introduce attendees to the unique characteristics and challenges of designing, conducting, and implementing ePCTs within diverse health care systems.
  • To increase the capacity of health services researchers to address important clinical questions with ePCTs.
Seminar Details & Registration
Saturday, June 1, 2019
8 am to 5 pm
Walter E. Washington Convention Center
Washington, D.C.

May 5, 2018: New Article Explores Opportunities for Funding the Training of Future Health Services Researchers

In a new article, Dr. Vincent Mor, an NIH Collaboratory investigator, and Dr. Paul Wallace describe the history, current status, and opportunities for funding training in health services research (HSR). While the number of organizations seeking to solve problems with health services research has been expanding, direct government support for HSR is declining. The authors project 5 key challenges for the field and its professional development:

  • Formulating and prioritizing research topics
  • Whether to use team- or individual-based approaches
  • How new data sources, analytic methods, and the need for faster results affect supply and demand for HSR
  • Shifts from public to institutional funding and the associated effects on generalizability
  • Balancing proprietary concerns regarding data, predictive models, and study results with the need to improve public health and rapidly disseminate information

According to the authors, sustainable solution will involve active collaboration between those who use HSR as a part of decision-making (and will likely pay for it) and those who produce it.

“We believe that the key change needed to productively address the above challenges will be a closer collaboration between HSR users, especially health systems, and academic HSR training programs to work towards producing timely, internally relevant, and externally generalizable knowledge (Mor and Wallace 2018).”

Dr. Mor is a principal investigator for the Pragmatic Trial of Video Education in Nursing Homes (PROVEN) trial, one of the NIH Collaboratory Trials.

Mor V, Wallace P. 2018.  Funding the Training of Future Health Services Researchers. Health Services Research. doi:10.1111/1475-6773.12844.

CTTI Releases 2015 Annual Report


The Clinical Trials Transformation Initiative (CTTI) has released its Annual Report for 2015. The report describes major achievements from the previous year, including new recommendations and related tools and checklists for improving the safety, efficiency, and overall quality of clinical research.

Cover page of CTTI Annual Report with embedded link to CTTI webpage containing report.
2015 CTTI Annual Report

Highlights of the 2015 Annual Report include recommendations on topics including:

  • Ethics review processes
  • Good Clinical Practice training for trial investigators
  • Research protocol design
  • Engagement of patient groups as equal partners in clinical research
  • Informed consent processes
  • Safety reporting systems for research participants

A public-private partnership whose many stakeholders include government agencies, advocacy groups, professional societies, academic research organizations, and representatives from the medical products industry, CTTI’s mission is to “identify and promote practices that will increase the quality and efficiency of clinical trials.”

Previous Annual Reports are also available on the CTTI website.