March 27, 2024: A Cluster Randomized Trial to Improve Kidney Transplant Access, in This Week’s PCT Grand Rounds

Drs. Amit Garg and Stephanie Dixon

In this Friday’s PCT Grand Rounds, Amit Garg and Stephanie Dixon of Western University’s Schulich School of Medicine and Dentistry will present “Effect of a Multicomponent Intervention to Improve Patient Access to Kidney Transplant and Living Kidney Donation: A Pragmatic, Cluster-Randomized Trial.”

The Grand Rounds session will be held on Friday, March 27, 2024, at 1:00 pm eastern.

Garg is the associate dean for clinical research at the Schulich School of Medicine and Dentistry and the lead of the provincial Kidney, Dialysis and Transplantation Program of the Institute for Clinical Evaluative Sciences (ICES KDT). Dixon is a biostatistician at the London Health Sciences Centre and the program manager for ICES KDT.

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March 20, 2024: Early Diagnosis and Assessment of Autism to Be Featured in This Week’s PCT Grand Rounds

Headshot of Dr. Warren Jones
Dr. Warren Jones

In this Friday’s PCT Grand Rounds, Warren Jones of Emory University will present “Early Diagnosis and Assessment of Autism via Objective Measurements of Social Visual Engagement.”

The Grand Rounds session will be held on Friday, March 22, 2024, at 1:00 pm eastern.

Jones is the director of research at the Marcus Autism Center and the Norman Nien Distinguished Chair in Autism and an associate professor of pediatrics at the Emory University School of Medicine.

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March 13, 2024: In This Friday’s PCT Grand Rounds, a Pragmatic Trial of Antibiotic Choice on Renal Outcomes

Headshot of Dr. Edward Qian
Dr. Edward Qian

In this Friday's PCT Grand Rounds, Edward Qian of Vanderbilt University will present "The Effect of Antibiotic Choice on Renal Outcomes: The ACORN Trial."

The Grand Rounds session will be held on Friday, March 15, 2024, at 1:00 pm eastern.

The ACORN trial compared the effects of cefepime vs piperacillin-tazobactam on the incidence of acute kidney injury among acutely ill adults. In this innovative study, randomization of eligible patients occurred at the prescriber level within the electronic medical record.

Qian, the principal investigator for ACORN, is an assistant professor of medicine and the assistant director for quality and education of the medical ICU at the Vanderbilt University Medical Center.

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March 6, 2024: In This Week’s PCT Grand Rounds, Public-Private Partnerships in Health AI

In this Friday’s PCT Grand Rounds, Michael Pencina of Duke University will present “Public-Private Partnerships in the Trustworthy Health AI Ecosystem.”

The Grand Rounds session will be held on Friday, March 8, 2024, at 1:00 pm eastern.

Pencina is a professor of biostatistics and bioinformatics and the vice dean for data science in the Duke University School of Medicine. He is the director of the university’s Duke AI Health initiative and the chief data scientist for Duke Health.

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February 28, 2024: A Randomized Trial of a Food-as-Medicine Program, in This Week’s PCT Grand Rounds

In this Friday’s PCT Grand Rounds, Joseph Doyle of the Massachusetts Institute of Technology (MIT) will present “Effect of an Intensive Food-as-Medicine Program on Health and Healthcare Use: Evidence From a Randomized Clinical Trial.”

The Grand Rounds session will be held on Friday, March 1, 2024, at 1:00 pm eastern.

Doyle is the Erwin H. Schell Professor of Management and Applied Economics at the MIT Sloan School of Management. His healthcare research includes partnering with large healthcare systems to conduct randomized trials of changes in the ways healthcare is delivered.

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February 21, 2024: In This Week’s PCT Grand Rounds, Virtual Monitoring in Decentralized Clinical Trials

In this Friday’s PCT Grand Rounds, Adrian Hernandez and Christopher Lindsell of Duke University will present “Virtual Vigilance: Monitoring of Decentralized Clinical Trials.”

The Grand Rounds session will be held on Friday, February 23, 2024, at 1:00 pm eastern.

Hernandez is the executive director of the Duke Clinical Research Institute (DCRI) and professor of medicine and vice dean in the Duke University School of Medicine. He also serves as co-principal investigator of the NIH Pragmatic Trials Collaboratory Coordinating Center. Lindsell is the director of data science and biostatistics at the DCRI and professor and cochief of biostatistics in the Department of Biostatistics and Bioinformatics in the Duke University School of Medicine.

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February 19, 2024: Virtual Monitoring in Decentralized Trials, in This Week’s PCT Grand Rounds

In this Friday’s PCT Grand Rounds, Adrian Hernandez and Christopher Lindsell of Duke University will present “Virtual Vigilance: Monitoring of Decentralized Clinical Trials.”

The Grand Rounds session will be held on Friday, February 23, 2024, at 1:00 pm eastern.

Hernandez is the executive director of the Duke Clinical Research Institute (DCRI) and professor of medicine and vice dean in the Duke University School of Medicine. He also serves as co-principal investigator of the NIH Pragmatic Trials Collaboratory Coordinating Center. Lindsell is the director of data science and biostatistics at the DCRI and professor and cochief of biostatistics in the Department of Biostatistics and Bioinformatics in the Duke University School of Medicine.

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February 14, 2024: In This Friday’s PCT Grand Rounds, Clinical Implications of the MINT Trial

Dr. Jeffrey Carson

In this Friday’s PCT Grand Rounds, Jeffrey Carson of Rutgers Biomedical and Health Sciences will present “Clinical Implications of the MINT Trial: p=0.07.”

The Grand Rounds session will be held on Friday, February 16, 2024, at 1:00 pm eastern.

Carson is provost-New Brunswick for Rutgers Biomedical and Health Sciences and the Distinguished Professor of Medicine and Richard C. Reynolds, MD, Chair in General Internal Medicine at Rutgers Robert Wood Johnson Medical School.

Carson will discuss the clinical implications of the Myocardial Ischemia and Transfusion (MINT) trial, a pragmatic clinical trial that did not show a significant difference between the study arms in the primary outcome yet consistently favored one intervention strategy in the point estimates for the primary and secondary outcomes.

The goal of the MINT trial was to determine whether the risk of recurrent myocardial infarction or death at 30 days differed between a restrictive transfusion strategy and a liberal transfusion strategy among patients with an acute myocardial infarction and anemia. The pragmatic trial’s broad inclusion criteria resulted in a study population with a variety of diagnoses and coexisting illnesses that was generally representative of patients in clinical practice. The trial’s transfusion protocols approximated clinical practice in a variety of healthcare settings.

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February 7, 2024: Pragmatic Recruitment of Underrepresented Groups, in This Week’s PCT Grand Rounds

In this Friday’s PCT Grand Rounds, Cynthia Hau of the VA Boston Health Care System will present “Pragmatic Recruitment of Underrepresented Groups: Experience From the Diuretic Comparison Project.”

The Grand Rounds session will be held on Friday, February 9, 2024, at 1:00 pm eastern.

Hau is a statistician for the VA Cooperative Studies Program Coordinating Center in the VA Boston Health Care System. Hau recently led a secondary analysis of the Diuretic Comparison Project presenting a centralized electronic health record–based model for the recruitment of participants from underrepresented groups.

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January 31, 2024: Improving the Public’s Understanding of the FDA, in This Week’s PCT Grand Rounds

In this Friday's PCT Grand Rounds, Susan Winckler of the Reagan-Udall Foundation for the FDA will present "Strategies for Improving Public Understanding of FDA and the Products It Regulates: Why Should We Care, and What Might We Do?"

The Grand Rounds session will be held on Friday, February 2, 2024, at 1:00 pm eastern.

Winckler is the chief executive officer of the Reagan-Udall Foundation for the FDA, a nonprofit organization created by Congress “to advance the mission of the FDA to modernize medical, veterinary, food, food ingredient, and cosmetic product development, accelerate innovation, and enhance product safety.”

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